A One-Year Randomized Controlled Clinical Trial of Three Types of Narrow-Diameter Implants for Fixed Partial Implant-Supported Prosthesis in the Mandibular Incisor Area.

Narrow-diameter implants (NDI) serve as a solution for treating limited bone volume in the anterior mandible. This study aimed to evaluate the one-year clinical outcomes of various NDIs in the mandibular incisor area after immediate loading in partially edentulous patients. This single-center, prospective, single-blinded, randomized controlled trial study included 21 patients, with 7 patients in each of the following groups: control (BLT NC SLActive®; Straumann), experimental group 1 (CMI IS-III Active® S-Narrow; Neobiotech), and experimental group 2 (CMI IS-III Active® Narrow; Neobiotech). Using full digital flow, two fixtures were placed in each patient and immediately provisionalized on the day of surgery. Evaluations encompassed periapical radiographs, implant stability quotient (ISQ), implant stability test (IST) readings, per-implant soft tissue health, patient satisfaction surveys, and esthetic score assessments. Definitive prostheses were delivered twelve weeks post-surgery (CRiS, number: KCT0007300). Following exclusions due to low stability values (n = 2), fixture failure (n = 5), and voluntary withdrawal (n = 1), the implant success rate for patients completing all clinical protocols stood at 100%. The resulting patient failure rates in the control, experimental group 1, and experimental group 2 were 50.0%, 42.9%, and 14.3%, respectively. There were no significant differences between the groups in terms of marginal bone loss, soft tissue health, patient satisfaction, and esthetic scores. Narrow implants showed superior clinical outcomes, followed by S-Narrow and Straumann implants. Calculated one-year survival rates at the implant level were 66.7% for the control group, 85.7% for experimental group 1, and 100% for experimental group 2. All three types of NDIs showed acceptable clinical and radiographic results during the year-long observation period.

Comparison of Implant Surgery Methods of Cortical Tapping and Cortical Widening in Bone of Various Density: A Three-Dimensional Finite Element Study.

PURPOSE: The primary stability of a dental implant is critical for successful osseointegration during immediate loading. The cortical bone should be prepared to achieve enough primary stability, but not overcompressed. In this study, we investigated the stress and strain distribution in the bone around the implant induced by the occlusal force applied during immediate loading at various bone densities by the FEA method to compare cortical tapping and widening surgical techniques. MATERIALS AND METHODS: A three-dimensional geometrical model of a dental implant and bone system was created. Five types of bone density combination (D111, D144, D414, D441 and D444) were designed. Two surgical methods-cortical tapping and cortical widening-were simulated in the model of the implant and bone. An axial load of 100 N and an oblique load of 30 N were applied to the crown. The maximal principal stress and strain were measured for comparative analysis of the two surgical methods. RESULTS: Cortical tapping showed lower maximal stress of bone and maximal strain of bone than cortical widening when dense bone was located around the platform, regardless of the direction of the applied load. CONCLUSIONS: Within the limitations of this FEA study, it can be concluded that cortical tapping is biomechanically more advantageous to the implants under occlusal force during immediate loading, especially when the bone density around the platform is high.

Early Loading of Mandibular Molar Single Implants: 1 Year Results of a Randomized Controlled Clinical Trial.

The purpose of this study was to compare the implant survival, peri-implant marginal bone level, and peri-implant soft tissue of three different types of implants. This was performed with an early loading protocol, using a complete digital workflow, for one year of follow-up. Twenty-four patients with a single missing tooth in the mandibular posterior region were randomly assigned to the control group (SLActive Bone level implant; Institut Straumann AG, Basel, Switzerland), experiment group 1 (CMI IS-III Active implant; Neobiotech Co., Seoul, Korea), and experiment group 2 (CMI IS-III HActive implant; Neobiotech Co., Seoul, Korea). For each patient, a single implant was installed using the surgical template, and all prostheses were fabricated using a computer-aided design/computer-aided manufacturing system on a 3-dimensional model. A provisional prosthesis was implanted at 4 weeks, and a definitive monolithic zirconia prosthesis was substituted 12 weeks following the implant placement. The implant stability quotient (ISQ) and peri-implant soft tissue parameters were measured, and periapical radiographs were taken at 1, 3, 4, 8, 12, 24, 36, and 48 weeks after implant placements. Seven implants in the control group, nine implants in the experiment 1 group, and eight implants in the experiment 2 group were analyzed. There were no significant differences among the three groups in terms of insertion torque, ISQ values between surgery and 8 weeks of follow-up, marginal bone loss at 48 weeks of follow-up, and peri-implant soft tissue parameters (P > 0.05). Statistically significant differences in ISQ values were observed between the control and experiment 1 groups, and the control and experiment 2 groups at the 12 to 48 weeks' follow-ups. Within the limits of this prospective study, an early loading protocol can be applied as a predictable treatment modality in posterior mandibular single missing restorations, achieving proper primary stability.

A New Method of Measuring the Volumetric Change of Alveolar Bone Around Dental Implants Using Computed Tomography.

This study proposes a method for measuring the volumetric change of alveolar bone after dental implant surgery using computed tomography (CT). A total of 40 implants in 20 patients (15 males and 5 females) were selected. The types of implants used were group 1: 24 CMI IS-II Active implants (Neobiotech Co., Seoul, Republic of Korea) and group 2: 16 SLActive Bone Level implants (Institut Straumann AG, Basel, Switzerland). The OnDemand3D software (CyberMed, Seoul, Korea) was used for analysis. The volumetric change of the alveolar bone around an implant fixture is measured as follows: (1) Establish two cylinders: the main cylinder with the implant axis as the central axis (radius of implant + 3 mm) and the error correction cylinder (radius of implant + 1 mm). (2) The height of the cylinder extended from the top of the fixture to a 3 mm coronal portion. (3) Calculate the volumetric change of the alveolar bone (Vd) by subtracting the volume of the error correction cylinder from the main cylinder between CT images taken immediately after the implant placement and 12 months later. After a one-year installation, the volumetric change of alveolar bone, ΔV (cc) had increased in both groups (group 1: -0.011 ± 0.015 cc, group 2: -0.012 ± 0.017 cc) with statistical significance (p < 0.05), and the difference between the groups was not statistically significant (p > 0.05). This three-dimensional assessment method would be a useful clinical reference for the assessment of marginal bone change after implant surgery.

Methods Used to Assess the 3D Accuracy of Dental Implant Positions in Computer-Guided Implant Placement: A Review.

The purpose of this review is to examine various assessment methods in order to compare the accuracy between the virtually planned and clinically achieved implant positions. In this review, comparison methods using pre- and post-operative computed topography (CT) data and digital impressions for definitive prosthesis will be described. The method for the displacement and strain for quantification of the error will also be explored. The difference between the planned and the actual implant placement position in guided implant surgery is expressed as an error. Assessing the accuracy of implant-guided surgery can play an important role as positive feedback in order to reduce errors. All of the assessment methods have their own inevitable errors and require careful interpretation in evaluation.

Effects of fluoride-modified titanium surfaces with the similar roughness on RUNX2 gene expression of osteoblast-like MG63 cells.

Chemical modification of titanium surfaces by hydrofluoric acid (HF) is an effective method to improve bone responses on titanium implant surfaces. In this study, titanium disks were sandblasted with titanium oxide grits and modified with 0.2% and 0.4% of diluted HF under different exposure times of 40 and 60 s. Surface characteristics, such as surface chemical composition, surface topography, and surface wettability, were investigated. To examine MG63 osteoblast-like cell responses to fluoride-modified titanium surfaces with roughness similar to that of nonmodified surfaces, a cell proliferation assay was performed and gene expression levels of Runx2 were evaluated using real-time PCR. Fluoride-modified titanium surfaces revealed no significant roughness difference but with hydrophilic properties than control group SB. Moreover, the relative atomic concentration percentages of fluoride were 0.7, 1.5, and 2.8. As fluoride concentrations increased, surface wettability increased and cell proliferation began earlier. However, the gene expression levels of Runx2 increased earlier on surfaces with 1.5% fluoride, with significantly high surface skewness. There seems to be an optimal fluoride concentration percentage when gene expression levels of Runx2 were taken into consideration. In addition, surface parameters, such as surface wettability and surface skewness, seem to be important factors in the enhancement of osteoblast differentiation by HF. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3102-3109, 2017.

Early loading of splinted implants supporting a two-unit fixed partial denture in the posterior maxilla: 13-month results from a randomized controlled clinical trial of two different implant systems.

OBJECTIVES: The aim of this study was to evaluate early-loaded implants supporting a two-unit fixed dental prosthesis in the posterior maxilla and to compare the clinical and radiological outcomes of two different implant systems in terms of success rates, implant stability quotient (ISQ) values, and peri-implant parameters. MATERIALS AND METHODS: Thirty patients with the unilateral loss of two consecutive maxillary posterior teeth were randomly assigned to two different implant systems: SLActive Bone level implant (Institut Straumann AG, Basel, Switzerland) in the control group and CMI IS-II active implant (Neobiotech Co., Seoul, Korea) in the experimental group. The patients received provisional and definitive two-unit fixed prostheses at 4 weeks and 6 months after implant surgery, respectively. The peak insertion torque was recorded at surgery. The stability of each implant was evaluated during surgery and at 2, 3, and 4 weeks and 6 and 13 months after implant placement by means of ISQ values. In addition, periapical radiographs and peri-implant parameters were taken throughout the trial. RESULTS: Overall, comparable results were obtained between the control and experimental groups in terms of insertion torque, ISQ values, marginal bone loss, and peri-implant soft tissue parameters. All 60 implants had 100% of success rate. The average insertion torque was 36.83 ± 6.09 (control) and 35.33 ± 3.20 (test) Ncm. The ISQ values remained steady until 4 weeks and then increased with statistical significance during 4 weeks to 13 months after surgery. Both groups exhibited no stability dip during the early phase of healing. The average marginal bone loss from the baseline of implant placement for the control and experimental groups was 0.38 and 0.45 mm after 4 weeks and 0.98 and 0.61 mm after 13 months. All of the soft tissue parameters were within normal limits. CONCLUSIONS: The results of this study indicate that the concept of early loading at 4 weeks after placement in the posterior maxilla can be an effective treatment option, even in the areas of low bone density, when implants satisfy the inclusion criteria of minimum insertion torque and ISQ of 30 Ncm and 65, respectively.

Prosthodontic rehabilitation after myofascial flap surgery of hemimaxillectomy defects in the edentulous patient: a clinical report.

OBJECTIVE: The aims of this clinical report were to present and discuss the clinical procedure and the treatment considerations of prosthetic rehabilitation after myofascial flap surgery. DESIGN: A 78-year-old edentulous woman with a squamous cell carcinoma underwent hemimaxillectomy. A temporalis myofascial flap surgery combined with implant-supported prosthesis is one successful approach to the restoration of oral function after hemimaxillectomy. CONCLUSIONS: Although the bulky and mobile nature of a temporalis myofascial flap prevented the retention of a tissue-borne denture, an appropriate impression technique and the fabrication of implant-supported prosthesis using an implant attachment system enhanced the overall satisfaction by the patient.

Comparison of the centering ability of Wave·One and Reciproc nickel-titanium instruments in simulated curved canals.

OBJECTIVES: The aim of this study was to evaluate the shaping ability of newly marketed single-file instruments, Wave·One (Dentsply-Maillefer) and Reciproc (VDW GmbH), in terms of maintaining the original root canal configuration and curvature, with or without a glide-path. MATERIALS AND METHODS: According to the instruments used, the blocks were divided into 4 groups (n = 10): Group 1, no glide-path / Wave·One; Group 2, no glide-path / Reciproc; Group 3, #15 K-file / Wave·One; Group 4, #15 K-file / Reciproc. Pre- and post-instrumented images were scanned and the canal deviation was assessed. The cyclic fatigue stress was loaded to examine the cross-sectional shape of the fractured surface. The broken fragments were evaluated under the scanning electron microscope (SEM) for topographic features of the cross-section. Statistically analysis of the data was performed using one-way analysis of variance followed by Tukey's test (α = 0.05). RESULTS: The ability of instruments to remain centered in prepared canals at 1 and 2 mm levels was significantly lower in Group 1 (p < 0.05). The centering ratio at 3, 5, and 7 mm level were not significantly different. CONCLUSIONS: The Wave·One file should be used following establishment of a glide-path larger than #15.

Stress shielding and fatigue limits of poly-ether-ether-ketone dental implants.

The poly-ether-ether-ketone (PEEK) polymer is of great interest as an alternative to titanium in orthopedics because of its biocompatibility and low elastic modulus. This study evaluated the fatigue limits of PEEK and the effects of the low elastic modulus PEEK in relation to existing dental implants. Compressive loading tests were performed with glass fiber-reinforced PEEK (GFR-PEEK), carbon fiber-reinforced PEEK (CFR-PEEK), and titanium rods. Among these tests, GFR-PEEK fatigue tests were performed according to ISO 14801. For the finite element analysis, three-dimensional models of dental implants and bone were constructed. The implants in the test groups were coated with a 0.5-mm thick and 5-mm long PEEK layer on the upper intrabony area. The strain energy densities (SED) were calculated, and the bone resorption was predicted. The fatigue limits of GFR-PEEK were 310 N and were higher than the static compressive strength of GFR-PEEK. The bone around PEEK-coated implants showed higher levels of SED than the bone in direct contact with the implants, and the wider diameter and stiffer implants showed lower levels of SED. The compressive strength of the GFR-PEEK and CFR-PEEK implants ranged within the bite force of the anterior and posterior dentitions, respectively, and the PEEK implants showed adequate fatigue limits for replacing the anterior teeth. Dental implants with PEEK coatings and PEEK implants may reduce stress shielding effects. Dental implant application of PEEK polymer-fatigue limit and stress shielding.

The importance of remaining teeth reconstruction in the definite obturator for a hemimaxillectomy patient.

OBJECTIVE: The aim of this clinical report was to present and discuss the clinical procedure and the treatment considerations of prosthetic rehabilitation for hemimaxillectomy patients. DESIGN: A 61-year-old man was successfully treated with all the remaining teeth reconstruction including replacing the implant-supported anterior fixed prosthesis and maxillary obturator. CONCLUSIONS: An appropriate obturator design, remaining teeth reconstruction, and establishment of a proper vertical dimension of occlusion are important for acceptable facial appearance and patient satisfaction.

Self-cutting blades and their influence on primary stability of tapered dental implants in a simulated low-density bone model: a laboratory study.

OBJECTIVE: This study tested the hypothesis that there would be differences in primary stability due to the presence of self cutting blades. We investigated the effect of a self-cutting blade implant design on the primary stability of tapered dental implants in a simulated low-density bone model. STUDY DESIGN: Implant fixtures with 2 different designs, one with self-cutting blades and the other without self-cutting blades, were fabricated in the same implant system. Insertion torque, resonance frequency analysis, reverse torque, and pull-out and push-in tests were evaluated in grade no. 10 solid rigid polyurethane foam. RESULTS: All 5 assessments of the group without self-cutting blades were significantly higher than those of the self-cutting group (P < .001). CONCLUSIONS: The implants without self-cutting blades create a lateral compression with increased contact surface area and consequently improve the primary stability in a simulated low-density bone model.

Microrough titanium surface affects biologic response in MG63 osteoblast-like cells.

The purpose of this study was to define the surface properties of prepared titanium (Ti) disks, which served as a model system, and to contrast the biologic response of MG63 cells exposed to Ti disks with different levels of surface roughness. The surface properties interact with each other, resulting in a change of other surface qualities in addition to roughness due to the surface roughening procedure. The machined Ti disks were roughened by sandblasting and electric glow discharging. The surface properties of the Ti specimens were inspected through a comprehensive surface analysis. MG63 cell behaviors were compared along with cell number, alkaline phosphatase (ALP) activity, Runx2 gene expression, and type I collagen production. Statistics were evaluated, using analysis of variance (ANOVA). The sandblasted Ti disks demonstrated well-controlled surface roughness features and meaningful average roughness ranges, including the surface roughness of the "modern" microrough implant, used clinically. With increasing Ti surface roughness, the cell number decreased, while the ALP activity, type I collagen production, and Runx2 gene expression increased significantly. The rougher the Ti surface was, the sooner the Runx2 gene was expressed. Based on these results, we suggest that the microrough Ti surfaces of the 1-3 mum range may contribute effectively to osteogenic differentiation and proliferation in MG63 cells.